Research areas

Nanotechnology

Nanotechnology is a science, engineering, and technology conducted at a scale of about 1 to 100 nanometers which provides new materials viz. nanoparticles, nanofibers, etc. with many potential applications in pharmaceutical research and clinical medicine. The nanotechnology lab focuses on the development of novel drug delivery systems with nanoparticles, polymer nanofibers, nanocomposites for CNS disorders, wound healing, bone regeneration, dentin regeneration etc.

We are developing thermosensitive insitu gelling systems for drug delivery for bone pathologies. In collaboration with Vishnu Dental College, Bhimavaram the nanomaterials are tailor-made to meet the clinical problems such as dental caries, gingival and periodontal pathologies.

  1. Development of Simvastatin Electrospun Fibers: A Novel Approach For Sustained Drug Delivery. Journal of Pharmaceutical Investigation, 2015.
    https://www.infona.pl/resource/bwmeta1.element.springer-6c0f6588-ecf4-36d6-b0fc-2f74ed35f329.
  1. Dissolution Rate Enhancement of Nimesulide Using Electro Spinning aqnd Cogrinding Techniques: A Comparative Study. American Journal o f Pharmtech Research. 2015.
    http://www.ajptr.com/archive/volume-5/august-2015-issue-4.html

Drug Discovery – Medicinal Chemistry

We all are aware of resistance development by various bacteria/fungi/protozoa’s. It has posed challenges and threat to mankind in the recent past. This resistance development by microorganisms has disposed many of the currently available drugs.

Further due to industrial/vehicular pollution and change of life style, the rate of asthma is increasing day by day causing the major economic crunch to the society not only nationally but also globally.

In this context, we in Med. Chem. Dept., at SVCP have designed and synthesized NCE’s (Novel Chemical Entities) targeting various infectious diseases caused by drug resistant/susceptible species of Mycobacterium tuberculi, Plasmodium falciparum etc and also developing chemical moieties targeting P1 receptors to treat asthmatic condition. Three of the NCE’s developed at our labs are in the final stages of the grant of patents.

One of the unique features of our department is strong research collaborations with various institutes like Uni-Bonn, Uni-Wuerzberg, NIH-Bethesda, Lousonia State Univ., National Institute for Malarial Research etc.

  1. Synthesis and adenosine receptors binding studies of new fluorinated analogues of pyrido[2,3-d]pyrimidines and quinazolines. Med Chem Res. 2018
    https://www.researchgate.net/publication/320640221
  2. Synthesis, Adenosine Receptor Binding and Molecular Modeling Studies of Novel    Thieno[2,3-d]pyrimidine Derivatives, Chem. Biol. Drug Desgn” 2018.
    https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13155
  3. Protective Effect of A2B Receptor Antagonist (TRP 1) on Acetic Acid Induced Ulcerative Colitis in Rats: in vitro, in vivo and in silico Methods, IJPER, 2018.
    https://www.researchgate.net/publication/326844895
  4. Ultrasound Assisted Cu-Catalyzed Synthesis Of 1,2-Disubstituted Benzimidazoles As Potential Antibacterial Agents. Mini-Reviews In Medicinal Chemistry. 2018.
    https://www.ingentaconnect.com/content/ben/mrmc/2018/00000018/00000014/art00008.
  5. 2-Amino Analogues Of Alkynyl Substituted 1,4-Dihydropyrimidine: Their Synthesis And Evaluation As Potential Antimicrobial / Cytotoxic Agents. Letters in drug design and discovery. 2018.
    https://benthamscience.com/journals/letters-in-drug-design-and-discovery/volume/15/issue/10/
  6. Detection Of Cytochrome P450 Polymorphisms In Breast Cancer Patients May Impact On Tamoxifen Therapy. Asian Pacific Journal Of Cancer Prevention, 2017.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980918/

Drug Discovery – Medicinal Chemistry

Natural products possess enormous structural and chemical diversity that cannot be matched by any synthetic libraries of small molecules and continue to inspire novel discoveries in chemistry, biology, and medicine. They are evolutionarily optimized as drug-like molecules and remain the best sources of drugs and drug leads. Application of molecular biological techniques is increasing the availability of novel compounds that can be conveniently produced in bacteria or yeasts, and combinatorial chemistry approaches are being based on natural product scaffolds to create screening libraries that closely resemble drug-like compounds.

In this context, we isolated, characterized and screened for biological activities from Turnera ulmifolia, Turnera ulmifolia, Fagonia cretica, Limonia acidissima etc. We are also developing analytical methods on selected natural products and validate them.

  1. “Rhetoric To Reality”-Efficacy Of PunicaGranatum Peel Extract On Oral Candidiasis: An In Vitro Study. Journal Of Clinical And Diagnostic, 2017.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324484/
  1. Evaluation Of Anti Cataract Activity Of Isolated Fractions Of AlbiziaProcera Stem Bark Chloroform Extract: Targeting  Na+ K+ Atpase In Goat Lenses. Advances In Pharmacology And Toxicology, 2017.
    https://tafewaprimo.hosted.exlibrisgroup.com/primo_library/libweb/action/display.
  2. Evaluation of Antiulcer And Thrombolytic Activity Of Aqueous Extract Of Tiliacora Acuminate Bark In Albino Wistar Rats. Journal Of Chemical And Pharmaceutical Research, 2016.
    https://www.academia.edu/25099434/Evaluation_of_antiulcer_and_thrombolytic_activity_of_aqueous_extract_of_Tiliacora_acuminata_bark_in_albino_wistar_rats
  3. Pharmacognostic And Preliminary Phytochemical Investigation of Leaves Of Aralia Racemosa L. Pharmacognosy Journal, 2016.
    https://www.phcogj.com/article/141
  4. Evaluation o f In Vitro Anti Coagulant and In Vitro Anti Diabetic Activity of AlstoniaSchaloris Leaves. International Research Journal of Pharmacy, 2016.
    https://www.researchgate.net/publication/310835550.
  5. Pharmacognostic Study of Callistemon Citrinus L. Bark. International Journal of Pharmacy and Pharmaceutical Sciences, 2015.
    https://innovareacademics.in/journals/index.php/ijpps/article/view/3709/7657.
  6. Antihypertensive Activity Of The Ethanolic Extract Of Lantana Camara Leaves On High Salt Loaded Wistar Albino Rats. Pharmacognosy Journal, 2015.
    https://www.phcogj.com/sites/default/files/10.5530pj.2015.5.7.pdf.
  7. Anti-Seizure Activity Of Allium Cepa.L (Red Onion) Bulb On Maximal Electroshock (MES) Induced Seizure In Mice. International Journal Of Pharmacognosy And Phytochemical Research, 2015.
    http://impactfactor.org/PDF/IJPPR/7/IJPPR,Vol7,Issue6,Article31.pdf.
  8. Phyto Chemical Screening And Anti-Oxidant Activity Of Ethanolic Extract Of HeliotropiumIndicum. International Research Journal Of Pharmacy, 2015.
    https://irjponline.com/admin/php/uploads/2395_pdf.pdf.

Formulations

In the department of pharmaceutics, the primary research is being carried out on controlled release/ extended release drug delivery systems, electro-spun nanofibres, oral thin films (mouth dissolving films), oro-dispersible tablets (mouth dissolving tablets), gastro-retentive drug delivery systems (mucoadhesive microspheres/ microcapsules, gastric floating drug delivery systems).

  1. Phospholipid Complex Technique For Superior Bioavailability Of Phytoconstituents. Advanced Pharmaceutical Bulletin, 2017.
    https://www.researchgate.net/publication/316232380.
  1. Development & Evaluation Of Mucoadhesive Microspheres Of Roxatidine Acetate Hcl. International Journal Of Pharmatech Research, 2016.
    http://sphinxsai.com/2016/ph_vol9_no2/1/(124-133)V9N2PT.pdf.
  1. Design And Evaluation Of Microspheres Using Anti-Ulcer Agent Roxatidine. Der Pharmacia Lettre, 2016.
    https://www.scholarsresearchlibrary.com/articles/design-and-evaluation-of-microspheres-using-antiulcer-agent-roxatidine.pdf.
  1. Design And Evaluation Of Microspheres Loaded With Cimetidine. Der Pharmacia Lettre, 2016.
    https://www.scholarsresearchlibrary.com/articles/design-and-evaluation-of-microspheres-loaded-with-cimetidine.pdf.
  1. In Vitro And In Vivo Evaluation Of Cimetidine Loaded Mucoadhesive Microspheres. International Journal Of Drug Delivery, 2016.
    http://www.arjournals.org/index.php/ijdd/article/view/1873/pdf.
  1. Design  And In Vitro Evaluation Of Floating Microspheres Using  Roxatidine Acetate HCl. American Journal Of Pharmatech Research, 2016.
    http://www.ajptr.com/archive/volume-6/february-2016-issue-1.html.
  1. Effect Of Sodium Alginate In Combination With Hpmc K 100 M In Extending The Release Of Metoprolol Succinate From Its Gastro-Retentive Floating Tablets. Indian Journal Of Pharmaceutical Education And Research, 2015.
    http://www.ijper.org/sites/default/files/IJPER_49_3_11_0.pdf.
  1. Dose Calculation, Design And Development Of Nateglinide Matrix Tablets Using Quality By Design Approach And Its Pharmacokinetic Evaluation In Animal Model. Journal Of Pharmaceutical Investigation, 2015.
    https://www.semanticscholar.org/paper/Dose-calculation%2C-design-and-development-of-matrix.

Drug Discovery - Pharmacology

Drug discovery and development is an exciting and challenging process wherein success is possible only when there is novel hypothesis, excellent planning, perfect execution and a bit of luck for getting a drug approved for clinical use. Academic institutes have been successful in generating new hypotheses and validating the hypothesis with the limited resources. These inventions led to the creation of spin-off companies with an objective to further refining those hypotheses to make viable products. The pharmacology department faculty is relentlessly striving to generate new hypotheses and validate them with suitable test system. The faculty is focusing on the discovery of novel agents from both synthetic and natural sources for the treatment of neurological disorders, gastrointestinal disorders, metabolic disorders, autoimmune disorders, respiratory disorders etc.

  1. Kumar PP, Purushottam G, Gnananath K, Prasad K. Hibiscus plantinifolius Ameliorates Renal Oxidative Damage Induced by Gentamicin in Rats: By Targeting Membrane Bound enzymes. INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH. 2018 Apr 1;52(2):327-33.
    https://www.ijper.org/sites/default/files/IndJPhaEdRes_52_2_327.pdf
  1. Kumar PP, Santhosh G, Chandana MS, Prasad K, Prasad MR, Khasim S. Protective Effect of A2B Receptor Antagonist (TRP 2) on Acetic Acid Induced Ulcerative Colitis in Rats: In vitro, in vivo and in silico Methods. Indian J Physiol Pharmacol. 2018;62(3):327-38.
    https://www.researchgate.net/publication/326844895
  1. Kumar PP, Santhosh G, Chandana MS, Prasad K, Prasad MR, Khasim S. Protective Effect of A2B Receptor Antagonist (TRP 2) on Acetic Acid Induced Ulcerative Colitis in Rats: In vitro, in vivo and in silico Methods. Indian J Physiol Pharmacol. 2018;62(3):327-38.
    https://www.ijper.org/sites/default/files/IndJPhaEdRes_52_1_101.pdf
  1. Talluri MR, Killari KN, Manepalli NV, Konduri P, Bandaru KK. Protective effect of Canna indica on cerebral ischemia-reperfusion injury in rats. Agriculture and Natural Resources. 2017 Dec 1;51(6):470-7.
    https://www.sciencedirect.com/science/article/pii/S2452316X17300820
  1. Sridevi M, Rao TS, Naidu CG, Nagaraju B. LC-PDA-ORD Bioassay of S-(+) and R-(-) Colchicine on Rat Dried Blood Spots: Application to a Pharmacokinetic Study. Analytical Chemistry Letters. 2018 Jan 2;8(1):139-51.
    https://www.tandfonline.com/doi/abs/10.1080/22297928.2017.1422802
  1. Thota K, Prasad K, Rao MV. Detection of Cytochrome P450 Polymorphisms in Breast Cancer Patients May Impact on Tamoxifen Therapy. Asian Pacific journal of cancer prevention: APJCP. 2018;19(2):343.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5980918/
  1. Kumar PP, Ramesh A, Prasad K, Gnananath K. EVALUATION OF ANTI CATARACT ACTIVITY OF ISOLATED FRACTIONS OF ALBIZIA PROCERA STEM BARK CHLOROFORM EXTRACT: TARGETING NA+ K+ ATPASE IN GOAT LENSES. Advances in Pharmacology and Toxicology. 2017 Apr 1;18(1):1.
    http://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=09732381&AN=125113748&h=1BU9%2FMont6nGhAE4tatg5qT2gD%2BYQm7YMdY1zn%2FLJJitfetOYbukwaubFY%2FeFBq93%2FqgIbVptT5iJDYvOJmdsg%3D%3D&crl=c
  2. Evaluation o f Nephroprotective Activity o f Ethanolic Extract Of Annona Reticulata In Gentamicin And Cisplatin Induced Nephrotoxicity In Rats. Journal o f Pharmaceutical Sciences And Research, 2016.
    https://www.jpsr.pharmainfo.in/Documents/Volumes/vol8Issue09/jpsr08

Analytical Method Developments

The pharmaceutical products are playing foremost role in the health care system and become a part of day to day life as common commodity. In order to accomplish the intended purpose, the medicines are required to be ideal in terms of its identity, purity, safety and efficacy. The analytical techniques are emerged based on the physico-chemical properties of the drug substance and based on the property being measured for its qualitative and quantitative assessment. Many sophisticated analytical instruments are elicited, due to rapid expansion in the electronic and computational technologies.

  1. LC-PDA-ORD Bioassay Of S-(+) And R-(-) Colchicine On Rat Dried Blood Spots: Application To A Pharmacokinetic Study. Analytical Chemistry Letters, 2018.
    https://www.tandfonline.com/doi/abs/10.1080/22297928.2017.1422802
  1. Method Validation And Estimation Of Anagrelide Hydrochloride In Pharmaceutical Dosage By RP-HPLC Method. International Journal of Drug Development And Research, 2017.
    http://www.ijddr.in/drug-development/method-validation-and-estimation-of-anagrelide-hydrochloride-inpharmaceutical-dosage-by-rphplc-method.php?aid=20408.
  1. Simple And Rapid Method Development And Validation Of RP-HPLC Method  For The Determination Of Zidovudine Inn Human Plasma. Journal Of Pharmacy Research, 2016.
    http://jprsolutions.info/files/final-file 5701fdbdbb5937.83852020.pdf
  1. Analytical Method Development And Validation Of Simultaneous Estimation Of Amlodipine Besylate And Atorvastatin Calcium By RP-HPLC Method.Journal Of Chemical And Pharmaceutical Research, 2015.
    http://www.jocpr.com/abstract/analytical-method-development-and-validation-of-simultaneous-estimation-ofrnamlodipine-besylate-and-atorvastatin-calcium-2990.html